|
Sign In to gain access to subscriptions and/or personal tools.
|
Vascular Medicine, Vol. 8, No. 2,
77-81 (2003)
DOI: 10.1191/1358863x03vm474oa
Oral L-arginine improves endothelial function in healthy individuals older than 70 years
Stefanie M Bode-Böger
Institute of Clinical Pharmacology, University Hospital, Otto-von-Guericke University, Magdeburg, stefanie.bode-boeger{at}medizin.uni-magdeburg.de
Jochen Muke
Institute of Clinical Pharmacology, Hannover Medical School, University Hospital Hamburg-Eppendorf, Germany
Andrzej Surdacki
Institute of Clinical Pharmacology, Hannover Medical School, University Hospital Hamburg-Eppendorf, Germany
Georg Brabant
Department of Endocrinology (GB), Hannover Medical School, University Hospital Hamburg-Eppendorf, Germany
Rainer H Böger
Clinical Pharmacology Unit, Department of Pharmacology, University Hospital Hamburg-Eppendorf, Germany
Jürgen C Frölich
Institute of Clinical Pharmacology, Hannover Medical School, University Hospital Hamburg-Eppendorf, Germany
Ageing is associated with progressive endothelial dysfunction in normal humans. Flow-mediated dilation (FMD) of the brachial artery is impaired in elderly individuals with cardiovascular disease and vascular nitric oxide (NO) bioavailability is reduced. We investigated whether oral L-arginine, the substrate for NO synthesis, can improve impaired FMD in healthy very old people. In a prospective, double-blind, randomized crossover trial, 12 healthy old subjects (age 73.8 6 2.7 years) took L-arginine (8 g p.o. two times daily) or placebo for 14 days each, separated by a wash-out period of 14 days. FMD was determined by high-resolution ultrasound in the brachial artery during reactive hyperaemia. Baseline artery diameter was 3.88 6 0.18 mm. l-Arginine signifi cantly improved FMD (to 5.7 6 1.2%, p, 0.0001), whereas placebo had no effect (-0.25 6 0.7%; n.s.). After L-arginine, plasma levels of L-arginine increased signifi cantly (114.9 6 11.6 versus 57.4 6 5.0 mmol/l), but placebo had no effect. As NO synthesis can be antagonized by its endogenous inhibitor asymmetric dimethyl L-arginine (ADMA), we determined ADMA plasma concentrations, which were elevated at baseline in comparison to healthy middle-aged individuals (3.9 6 0.2 versus 1.0 6 0.1 mmol/l; p, 0.0001). ADMA remained unchanged during treatment, but L-arginine supplementation normalized the L-arginine/ADMA ratio (p, 0.05). We conclude that in healthy very old age endothelial function is impaired and may be improved by oral L-arginine supplementation, probably due to normalization of the L-arginine/ADMA ratio.
Key Words: ageing • asymmetric dimethylarginine • flow-mediated vasodilation • oral L-arginine
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Bryk, J. B. Ochoa, M. I. T. Correia, V. Munera-Seeley, and P. J. Popovic
Effect of Citrulline and Glutamine on Nitric Oxide Production in RAW 264.7 Cells in an Arginine-Depleted Environment
JPEN J Parenter Enteral Nutr,
July 1, 2008;
32(4):
377 - 383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Baylis
Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency
Physiology,
June 1, 2008;
23(3):
142 - 150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Heutling, H. Schulz, I. Nickel, J. Kleinstein, P. Kaltwasser, S. Westphal, F. Mittermayer, M. Wolzt, K. Krzyzanowska, H. Randeva, et al.
Asymmetrical Dimethylarginine, Inflammatory and Metabolic Parameters in Women with Polycystic Ovary Syndrome before and after Metformin Treatment
J. Clin. Endocrinol. Metab.,
January 1, 2008;
93(1):
82 - 90.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. K Rudolph, K. Ruempler, E. Schwedhelm, J. Tan-Andresen, U. Riederer, R. H Boger, and R. Maas
Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial
Am. J. Clinical Nutrition,
August 1, 2007;
86(2):
334 - 340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Toth, A. Racz, P. M. Kaminski, M. S. Wolin, Z. Bagi, and A. Koller
Asymmetrical Dimethylarginine Inhibits Shear Stress-Induced Nitric Oxide Release and Dilation and Elicits Superoxide-Mediated Increase in Arteriolar Tone
Hypertension,
March 1, 2007;
49(3):
563 - 568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. E. Gates, M. L. Boucher, A. E. Silver, K. D. Monahan, and D. R. Seals
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
J Appl Physiol,
January 1, 2007;
102(1):
63 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Mittermayer, K. Krzyzanowska, M. Exner, W. Mlekusch, J. Amighi, S. Sabeti, E. Minar, M. Muller, M. Wolzt, and M. Schillinger
Asymmetric Dimethylarginine Predicts Major Adverse Cardiovascular Events in Patients With Advanced Peripheral Artery Disease
Arterioscler. Thromb. Vasc. Biol.,
November 1, 2006;
26(11):
2536 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J.M. Broadley, A. Korszun, E. Abdelaal, V. Moskvina, J. Deanfield, C. J.H. Jones, and M. P. Frenneaux
Metyrapone Improves Endothelial Dysfunction in Patients With Treated Depression
J. Am. Coll. Cardiol.,
July 4, 2006;
48(1):
170 - 175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H.K. Vogel, S. F. Bolling, R. B. Costello, E. M. Guarneri, M. W. Krucoff, J. C. Longhurst, B. Olshansky, K. R. Pelletier, C. M. Tracy, R. A. Vogel, et al.
Integrating Complementary Medicine Into Cardiovascular Medicine: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine)
J. Am. Coll. Cardiol.,
July 5, 2005;
46(1):
184 - 221.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Scalera, J. Borlak, B. Beckmann, J. Martens-Lobenhoffer, T. Thum, M. Tager, and S. M. Bode-Boger
Endogenous Nitric Oxide Synthesis Inhibitor Asymmetric Dimethyl L-Arginine Accelerates Endothelial Cell Senescence
Arterioscler. Thromb. Vasc. Biol.,
October 1, 2004;
24(10):
1816 - 1822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. Gornik and M. A. Creager
Arginine and Endothelial and Vascular Health
J. Nutr.,
October 1, 2004;
134(10):
2880S - 2887S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. B. Soeters, M. C. G. van de Poll, W. G. van Gemert, and C. H. C. Dejong
Amino Acid Adequacy in Pathophysiological States
J. Nutr.,
June 1, 2004;
134(6):
1575S - 1582S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
