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Vascular Medicine, Vol. 9, No. 4, 293-301 (2004)
DOI: 10.1191/1358863x04vm572ra
© 2004 SAGE Publications

Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion

Eric P Brass

Center for Clinical Pharmacology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA

William R Hiatt

Department of Medicine, Divisions of Geriatrics and Cardiology, Section of Vascular Medicine, University of Colorado Health Sciences Center and the Colorado Prevention Center, Denver, CO, USA, will.hiatt{at}uchsc.edu

Simon Green

School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, Australia

Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

Key Words: blood flow • intermittent claudication • muscle metabolism • peripheral vascular disease


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