| Sign In to gain access to subscriptions and/or personal tools. |
DOI: 10.1191/1358863x03vm493ra Iron and peripheral arterial disease: revisiting the iron hypothesis in a different lightDepartment of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA
Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA
Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA, cooper.leslie{at}mayo.edu The relationship between iron status and atherosclerosis has long been a topic of debate in the literature. Despite more than 25 years of research, there is no consensus regarding a causal relationship. To date, the vast majority of studies have focused on iron burden with respect to a hypothesized role in the onset and progression of coronary artery disease. However, the effect of iron in the coronary arterial system may differ mechanistically and therefore clinically from its effect in the peripheral arterial system. This review will summarize the biochemical, pathologic, animal, and clinical research data with respect to iron and atherosclerosis. This background will be expanded upon to provide insights into ongoing studies and paths for future investigations into the role of iron and peripheral arterial disease.
Key Words: atherosclerosis coronary artery disease iron oxidative stress peripheral arterial disease
This article has been cited by other articles:
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||




