Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents
Vascular Medicine
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Janatuinen, T.
Right arrow Articles by Knuuti, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Janatuinen, T.
Right arrow Articles by Knuuti, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults

Tuula Janatuinen

Turku PET Centre, University of Turku, Finland

Juha Laakso

Department of Clinical Pharmacology, University of Helsinki, Finland

Reijo Laaksonen

Department of Clinical Pharmacology, University of Helsinki, Finland, Department of Medicine, University of Tampere, Finland

Risto Vesalainen

Turku PET Centre, University of Turku, Finland, Department of Medicine, University of Turku, Finland

Pirjo Nuutila

Turku PET Centre, University of Turku, Finland, Department of Medicine, University of Turku, Finland

Terho Lehtimäki

Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University Hospital of Tampere and Tampere University Medical School, Tampere, Finland

Olli T Raitakari

Turku PET Centre, University of Turku, Finland

Juhani Knuuti

Turku PET Centre, University of Turku, Finland, juhani.knuuti{at}utu.fi

Elevated plasma levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) are related to decreased myocardial vasodilatory capacity and increased risk of acute coronary events. As statin treatment is known to increase nitric oxide bioavailability and enhance myocardial function, we tested whether ADMA concentration modi-fies the effect of pravastatin on myocardial blood flow in young adults with mild hypercholesterolemia. Fifty-one men (35 ± 4 years) were randomly assigned to receive either pravastatin (40 mg/day) or placebo for 6 months. Myocardial blood flow was measured at rest and during adenosine-induced hyperemia using positron emission tomography and oxygen-15-labeled water at baseline and after treatment. Plasma ADMA levels were assessed with high performance liquid chromatography. Low baseline plasma ADMA concentration (< median) predicted a significant improvement of adenosine-induced blood flow after statin intervention (baseline to follow-up change +35%, p = 0.004), whereas high baseline ADMA (≥ median) was associated with no increase in adenosine-induced flow.

Key Words: asymmetric dimethylarginine • blood flow • positron emission tomography • pravastatin

Vascular Medicine, Vol. 8, No. 3, 185-189 (2003)
DOI: 10.1191/1358863x03vm490oa
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
G. I. Boger, T. K. Rudolph, R. Maas, E. Schwedhelm, E. Dumbadze, A. Bierend, R. A. Benndorf, and R. H. Boger
Asymmetric Dimethylarginine Determines the Improvement of Endothelium-Dependent Vasodilation by Simvastatin: Effect of Combination With Oral L-Arginine
J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2274 - 2282.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Meinitzer, U. Seelhorst, B. Wellnitz, G. Halwachs-Baumann, B. O. Boehm, B. R. Winkelmann, and W. Marz
Asymmetrical Dimethylarginine Independently Predicts Total and Cardiovascular Mortality in Individuals with Angiographic Coronary Artery Disease (The Ludwigshafen Risk and Cardiovascular Health Study)
Clin. Chem., February 1, 2007; 53(2): 273 - 283.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
R. H Boger
Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials
Vascular Medicine, July 1, 2005; 10(1_suppl): S19 - S25.
[Abstract] [PDF]

Home page
 Vasc MedHome page
R. Maas
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA)
Vascular Medicine, July 1, 2005; 10(1_suppl): S49 - S57.
[Abstract] [PDF]

Home page
 Vasc MedHome page
R. H Boger
Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials
Vascular Medicine, May 1, 2005; 10(2_suppl): S19 - S25.
[Abstract] [PDF]

Home page
 Vasc MedHome page
R. Maas
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA)
Vascular Medicine, May 1, 2005; 10(2_suppl): S49 - S57.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
R. H. Boger
Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Explains the "L-Arginine Paradox" and Acts as a Novel Cardiovascular Risk Factor
J. Nutr., October 1, 2004; 134(10): 2842S - 2847S.
[Abstract] [Full Text] [PDF]

Home page
 Vasc MedHome page
R. H Boger
Asymmetric dimethylarginine (ADMA) modulates endothelial function - therapeutic implications
Vascular Medicine, August 1, 2003; 8(3): 149 - 151.
[PDF]