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Vascular Medicine, Vol. 8, No. 2, 115-126 (2003)
DOI: 10.1191/1358863x03vm483ra

Functional outcomes and quality of life in peripheral arterial disease: current status

Mark R Nehler

Sections of Vascular Surgery, Departments of Surgery and Medicine, University of Colorado Health Sciences Center, Denver, CO, USA, mark.nehler{at}uchsc.edu

Mary M McDermott

Feinberg School of Medicine at Northwestern University, Chicago, IL, USA

Diane Treat-Jacobson

School of Nursing, University of Minnesota, Minneapolis, MN, USA

Ian Chetter

Department of Vascular Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia

Judith G Regensteiner

Section of Medicine, Department of Surgery and Medicine, University of Colorado Health Sciences Center, Denver, CO, USA

This review examines current evidence for baseline functional impairment and changes with therapy in patients with peripheral arterial disease (PAD) - ranging from patients without claudication or critical limb ischemia (CLI) but other exertional leg symptoms (erroneously referred to as asymptomatic in the Fontaine classifi cation system), to patients with claudication and those with CLI. The review points out that the status of functional outcomes research is markedly different in focus and development in the different levels of disease severity - paradoxically less studied in the more severe CLI population than in patients with claudication, for example.

Key Words: critical limb ischemia • intermittent claudication • outcomes • peripheral arterial disease • quality of life


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