Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to browse AJSM online!
Vascular Medicine
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mohler, E. R
Right arrow Articles by Crystal, R. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mohler, E. R, III
Right arrow Articles by Crystal, R. G
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Peripheral Arterial Disease
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial

Emile R Mohler, III

Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology University of Pennsylvania Health System, Philadelphia, PA, USA, mohlere{at}uphs.upenn.edu

Sanjay Rajagopalan

Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor, MI, USA

Jeffrey W Olin

Department of Internal Medicine, Mount Sinai Medical Center, New York, NY, USA

Jeffrey D Trachtenberg

Decatur Memorial Hospital Cardiac and Vascular Research Institute, Decatur, IL, USA

Henrik Rasmussen

GenVec Inc., Gaithersburg, MD, USA

Raphael Pak

Pfizer Global Research & Development, Ann Arbor, MI, USA

Ronald G Crystal

Department of Internal Medicine, Cornell University, New York, NY, USA

Critical limb ischemia (CLI) is typifi ed by rest pain and/or tissue necrosis secondary to advanced peripheral arterial disease (PAD) and is characterized by diminution in limb per-fusion at rest. We tested the safety of an angiogenic strategy with CI-1023 (AdGV VEGF121.10), a replication-defi cient adenovirus encoding human vascular endothelial growth factor isoform 121 in patients with CLI as part of a phase I trial. Fifteen subjects >35 years of age with CLI and angiographic disease involving the infra-inguinal vessels underwent intramuscular injection of CI-1023 (4 3 108 to 4 3 1010 particle units, n = 13) or placebo (n = 2). All of the patients tolerated the injection well and there were no serious complications related to the procedure. Transient edema was noted in one patient. A total of 79 adverse events were reported over the course of one year. One death (day 136) and one malignancy (day 332) occurred in the CI-1023 group. CI-1023 appears to be well tolerated and safe for single-dose administration in patients with critical limb ischemia due to PAD. Further studies are needed to determine the efficacy of this form of therapeutic angiogenesis.

Key Words: angiogenesis • endothelium

Vascular Medicine, Vol. 8, No. 1, 9-13 (2003)
DOI: 10.1191/1358863x03vm460oa
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arch SurgHome page
N. R. Sodha, M. Boodhwani, R. T. Clements, S.-H. Xu, K. R. Khabbaz, and F. W. Sellke
Increased Antiangiogenic Protein Expression in the Skeletal Muscle of Diabetic Swine and Patients
Arch Surg, May 1, 2008; 143(5): 463 - 470.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Rajagopalan, J. Olin, S. Deitcher, A. Pieczek, J. Laird, P. M. Grossman, C. K. Goldman, K. McEllin, R. Kelly, and N. Chronos
Use of a Constitutively Active Hypoxia-Inducible Factor-1{alpha} Transgene as a Therapeutic Strategy in No-Option Critical Limb Ischemia Patients: Phase I Dose-Escalation Experience
Circulation, March 13, 2007; 115(10): 1234 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Aramoto, J. W. Breslin, P. J. Pappas, R. W. Hobson II, and W. N. Duran
Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1590 - H1598.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. L. Duvall, W. Robert Taylor, D. Weiss, and R. E. Guldberg
Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H302 - H310.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Rajagopalan, E. R. Mohler III, R. J. Lederman, F. O. Mendelsohn, J. F. Saucedo, C. K. Goldman, J. Blebea, J. Macko, P. D. Kessler, H. S. Rasmussen, et al.
Regional Angiogenesis With Vascular Endothelial Growth Factor in Peripheral Arterial Disease: A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Claudication
Circulation, October 21, 2003; 108(16): 1933 - 1938.
[Abstract] [Full Text] [PDF]