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High circulating levels of cytokines (IL-6 and TNFa), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy, ssignore{at}unict.it

Maria Clorinda Mazzarino

Department of Medical Science - Section of Immunology, Faculty of Medicine, University of Catania, Hospital Garibaldi, Catania, Italy

Luigi Di Pino

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Grazia Malaponte

Department of Medical Science - Section of Immunology, Faculty of Medicine, University of Catania, Hospital Garibaldi, Catania, Italy

Carmela Porto

Department of Medical Science - Section of Immunology, Faculty of Medicine, University of Catania, Hospital Garibaldi, Catania, Italy

Giuseppe Pennisi

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Giuseppe Marchese

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Maria Pia Costa

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Daniele Digrandi

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Gabriella Celotta

Department of Internal Medicine and Medical Specialties, Hospital Garibaldi, Catania, Italy

Vittorio Virgilio

Department of Vascular Surgery, Hospital Garibaldi, Catania, Italy

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis that is associated with systemic inflammation. The aim of our study was to assess whether plasma markers of inflammation increased after exercise in patients with PAD. The study was conducted on two groups of 20 subjects each: one group (mean age 68.4 6 5.09 years) was affected by PAD with claudication, while the other group consisted of healthy controls (66.9 6 6.1 years). Concentrations of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFa) were determined in plasma, in supernatants and in cells stimulated with 1 mg lipopolysaccharide in all patients. E-selectin (ES), L-selectin (LS) and P-selectin (PS) concentrations and plasma concentrations of VCAM-1 and ICAM-I were also determined. All determinations were performed in patients at rest and after the treadmill exercise. Resting values of soluble mediators were greater in PAD patients than in controls. They increased in both groups after the treadmill test, even if post-treadmill concentrations were signifi cantly higher in PAD patients (PAD p < 0.001 or 0.0001, controls p < 0.05 or 0.001).

These results confi rm that white blood cell activation is characteristic of systemic atherosclerosis and that these inflammation markers increase in conditions of hemodynamic stress.

Key Words: inflammatory mediators • treadmill test • vascular disease

Vascular Medicine, Vol. 8, No. 1, 15-19 (2003)
DOI: 10.1191/1358863x03vm466oa


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