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Vascular Medicine, Vol. 7, No. 3, 241-246 (2002)
DOI: 10.1191/1358863x02vm433ra

Toward a new blood vessel

Briain D MacNeill

Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA

Irina Pomerantseva

Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA, Tissue Engineering Laboratories, Massachusetts General Hospital, Boston, MA, USA

Harry C Lowe

Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA

Stephen N Oesterle

Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA, Tissue Engineering Laboratories, Massachusetts General Hospital, Boston, MA, USA

Joseph P Vacanti

Tissue Engineering Laboratories, Massachusetts General Hospital, Boston, MA, USA, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA, jvacanti{at}partners.org

Strategies to treat atherosclerotic coronary artery disease include coronary artery bypass grafting (CABG), in which grafts are used to bypass atherosclerotic vessels and restore blood flow to the ischemic myocardium. The grafts used include healthy arteries or veins harvested from a separate site. Results with arterial grafts have been superior to venous grafts; promoting the practice of total arterial revascularization using only arterial grafts. Suitable arterial grafts, however, are scarce and harvest procedures add to morbidity and cost. Tissue engineering combines the principles of engineering with life sciences for the development of biological substitutes and restore, maintain or improve tissue function. Advances in this field have included the development of tissue-engineered blood vessels, with the potential to serve as arterial grafts, conduits or fistulae. This review describes the history of tissue engineering arteries, the techniques used, and progress to date. The source of cells and the future direction of this field are explored.

Key Words: atherosclerosis • bypass • coronary artery disease • revascularization • tissue engineering


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