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Diameter, pressure and compliance relationships in dorsal hand veins

Division of Clinical Pharmacology, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA, Shykoff{at}acsu.Buffalo.EDU

Feras I Hawari

Division of Clinical Pharmacology, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA

Joseph L Izzo, Jr

Division of Clinical Pharmacology, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA

The diameter-pressure characteristics of dorsal hand veins previously have not been characterized. In this study, the effects of distending pressure with and without infused norepinephrine on diameter and compliance were observed. The elevation needed for venous collapse was measured, and the effects of baseline constriction on venous reactivity were assessed. In seven supine subjects, a brachial cuff on an elevated arm was used to generate distending pressures while a linear variable displacement transformer (LVDT) measured changes in venous diameter. Arctangent functions of distending pressure were fitted to the normalized diameter, then compliance functions were calculated. In supine subjects, 5-15 cm of elevation emptied dorsal hand veins. Norepinephrine decreased the venous diameter at any distending pressure by increasing the P₅₀ without significantly changing the midpoint slope. Compliance was a nearly single-valued function of the normalized diameter with a maximum value at about 60% distention. Reactivity depends on distending pressure and baseline P₅₀. Percentage constriction is a function of initial and final P₅₀ and of distending pressure.

Key Words: drug effects • modeling • norepinephrine • stiffness • venous reactivity

Vascular Medicine, Vol. 6, No. 2, 97-102 (2001)
DOI: 10.1177/1358836X0100600205


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