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Vascular Medicine
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Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males

Won-Ha Lee

Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea, Pennington Biomedical Research Center, LSU, 6400 Perkins Road, Baton Rouge, LA, USA

Tae-Hong Hwang

Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea

Goo Taeg Oh

Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea

Sung Uk Kwon

Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Yoon-Ho Choi

Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Jeong-Euy Park

Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea, jepark{at}smc.samsung.co.kr

The maintenance of balance between nitric oxide (NO) and the superoxide anion is required for proper functioning of the endothelium. To investigate the relationship between genetic factors associated with endothelial function and the development of coronary artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male CAD patients and 215 healthy male control subjects. The ß-fibrinogen gene H1/H2 polymorphism was also analyzed. Both ecNOS a/b and p22 phox C242T polymorphisms were found to be associated with the development of CAD in the study population (p = 0.020 and 0.011, respectively). When the association was analyzed by age, statistical significance was retained only in those <51 years (p = 0.021 and 0.025 for the a/b and the C242T polymorphism, respectively) and not in those >51 years of age (p =0.155 and 0.278 respectively). However, the distribution of the ß-fibrinogen H1/H2 genotypes was not found to be associated with the development of CAD in either the ≤50 (p = 0.611) or >50 groups (p = 0.188). The ecNOS gene a/b polymorphism and the NADH/NADPH oxidase p22 phox gene C242T polymorphism were found to be significantly associated with the development of CAD in Korean male patients less than 51 years old.

Key Words: coronary artery disease • endothelial dysfunction • nitric oxide

Vascular Medicine, Vol. 6, No. 2, 103-108 (2001)
DOI: 10.1177/1358836X0100600206
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