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Vascular Medicine
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Statins and cerebrovascular disease: plaque attack to prevent brain attack

Emile R Mohler, III

Department of Medicine, Cardiovascular Disease Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Norman Delanty

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Daniel J Rader

Department of Medicine, Cardiovascular Disease Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Eric C Raps

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Stroke is the third leading cause of death in the USA and in the developed world. The beneficial role of cholesterol reduction in decreasing stroke has been uncertain. However, recent data indicate that statin treatment in patients with a history of myocardial infarction not only reduces the risk of a second myocardial infarction, coronary heart disease, revascularization procedures and death, but also significantly reduces the risk of stroke. However, the mechanism(s) by which statins reduce stroke remain uncertain. Thus, the therapeutic armamentarium for the reduction of stroke in secondary prevention now includes cholesterol reduction with statins.

Key Words: cholesterol • statins • stroke

Vascular Medicine, Vol. 4, No. 4, 269-272 (1999)
DOI: 10.1177/1358836X9900400410
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