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Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter

Department of Cardiovascular Diseases, No. 2 Affiliated Hospital, College of Medicine, Zhejiang Universityjian_an_wang{at}yahoo.com

Xiao-feng Chen

Department of Cardiovascular Diseases, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University; Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College

Wei-fang Yu

Department of Cardiovascular Diseases and Department of Medical Ultrasonics, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University

Han Chen

Department of Cardiovascular Diseases, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University

Xian-fang Lin

Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College

Mei-jiang Xiang

Department of Cardiovascular Diseases, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University

Cong-feng Fang

Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College

Yu-xi Du

Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College

Bin Wang

Department of Cardiovascular Diseases, Taizhou Hospital, Wenzhou Medical College

Abstract

The objective of this study was to examine the association of alcohol drinking and lipid profile with infrarenal aortic dimension. The diameter of the infrarenal aorta was measured using ultrasound in 395 individuals (mean 66.6 ± 10.3 years) with atherosclerotic diseases or risk factors. The associations between heavy drinking, serum lipoprotein (a) levels, lipid profile and infrarenal aorta diameters were examined. Heavy drinking and lipoprotein (a) were positively related with infrarenal aortic dimension, while low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), LDL-C and total cholesterol (TC)/HDL-C were negatively associated with infrarenal aortic diameter (p < 0.05). In addition, there were negative associations of LDL-C/HDL-C, TC/HDL-C and positive associations of HDL-C and apolipoprotein AI (Apo AI) with heavy drinking (p < 0.05). In conclusion, there was a positive association between infrarenal aortic diameters and heavy drinking, as well as lipoprotein (a) levels. Furthermore, the novel and unexpected inverse association between LDL-C/HDL-C, LDL-C, TC/HDL-C and abdominal aortic diameter may suggest a possible role for anti-atherogenic lipid profile (characterized by a higher level of HDL-C and lower level of LDL-C) in aortic dilatation processes, which need to be clarified by further studies.

Key Words: alcohol • aorta • lipids • lipoprotein (a)

Vascular Medicine, Vol. 14, No. 4, 323-329 (2009)
DOI: 10.1177/1358863X09104223


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