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Physical activity during daily life and brachial artery flow-mediated dilation in peripheral arterial diseaseNorthwestern University Feinberg School of Medicine
Northwestern University Feinberg School of Medicine
University of Texas
University of Vermont
University of Wisconsin
Northwestern University Feinberg School of Medicine
National Institute on Aging
University of California at San Diego School of Medicine
National Institute on Aging
Northwestern University Feinberg School of Medicine
Northwestern University Feinberg School of Medicine
University of Texas
Northwestern University Feinberg School of Medicine
Northwestern University Feinberg School of Medicine
Evanston Northwestern Hospital
Rush School of Medicine
DuPage Hospital
University of Illinois
Northwestern University Feinberg School of Medicinemdm608{at}northwestern.edu Abstract
We determined whether higher levels of physical activity in daily life are associated with better brachial artery flow-mediated dilation (FMD) among individuals with lower extremity peripheral arterial disease (PAD). Participants were 111 men and women with PAD (ankle–brachial index (ABI)
Key Words: endothelial reactivity • intermittent claudication • peripheral arterial disease • physical activity
Vascular Medicine, Vol. 14, No. 3,
193-201 (2009) |
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0.95) who completed baseline testing in the Study to Improve Leg Circulation (SILC). We evaluated FMD of the brachial artery at baseline and at 60 seconds following 4 minutes of suprasystolic blood pressure cuff inflation. Physical activity was measured continuously over 7 days using a vertical accelerometer (Caltrac) and a pedometer (Digiwalker). Adjusting for age, sex, race, ABI, cardiovascular risk factors and other potential confounders, higher levels of physical activity were associated with a greater percent change in brachial artery FMD at 60 seconds post cuff deflation for both Caltrac (1st tertile of activity +4.81% change; 2nd tertile +4.60% change; 3rd tertile +7.23% change; p-trend = 0.018) and the Digiwalker (1st tertile of activity +3.76% change; 2nd tertile +6.25% change; 3rd tertile +7.25% change; p-trend = 0.001). Similar findings were observed for absolute change in brachial artery FMD 60 seconds after cuff deflation. In conclusion, higher levels of physical activity during daily life are associated significantly and independently with better brachial artery FMD among individuals with PAD, even after adjusting for confounders. ClinicalTrials.gov Identifier: NCT00106327.