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Vascular Medicine
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research-article

Digital thermal monitoring of vascular function: a novel tool to improve cardiovascular risk assessment

Khawar M Gul

Harbor-UCLA Medical Center

Naser Ahmadi

Harbor-UCLA Medical Center

Zhiying Wang

University of Texas Houston Health Science Center

Craig Jamieson

Endothelix Inc.

Khurram Nasir

Cardiac MRI PET CT Program, Massachusetts General Hospital, Harvard Medical School

Ralph Metcalfe

University of Houston

Harvey S Hecht

Lenox Hill Heart & Vascular Institute

Craig J Hartley

Baylor College of Medicine

Morteza Naghavi

Society for Heart Attack Prevention and Eradication (SHAPE)

Abstract

Digital thermal monitoring (DTM) of vascular function during cuff-occlusive reactive hyperemia relies on the premise that changes in fingertip temperature during and after an ischemic stimulus reflect changes in blood flow. To determine its utility in individuals with and without known coronary heart disease (CHD), 133 consecutive individuals (age 54 ± 10 years, 50% male, 19 with known CHD) underwent DTM during and after 2 minutes of supra-systolic arm cuff inflation. Fingertip temperatures of the occluded and non-occluded fingertips were measured simultaneously. Post-cuff deflation temperature rebound (TR) was lower in the CHD patients and in those with an increased Framingham risk score (FRS) compared to the normal group. After adjustment for age, sex, and cardiac risk factors, TR was significantly lower in those with CHD compared to those without CHD (p < 0.05). This study demonstrates that vascular dysfunction measured by DTM is associated with CHD and an increased FRS, and could potentially be used to identify high-risk patients.

Key Words: coronary heart disease • digital thermal monitoring • endothelial function • Framingham risk score • reactive hyperemia • vascular reactivity

Vascular Medicine, Vol. 14, No. 2, 143-148 (2009)
DOI: 10.1177/1358863X08098850
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