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Vascular Medicine
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review-article

Collagens in the progression and complications of atherosclerosis

Eser Adiguzel

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Pamela J Ahmad

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Christopher Franco

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Michelle P Bendeck

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada michelle.bendeck{at}utoronto.ca

Abstract

Collagens constitute a major portion of the extracellular matrix in the atherosclerotic plaque, where they contribute to the strength and integrity of the fibrous cap, and also modulate cellular responses via specific receptors and signaling pathways. This review focuses on the diverse roles that collagens play in atherosclerosis; regulating the infiltration and differentiation of smooth muscle cells and macrophages; controlling matrix remodeling through feedback signaling to proteinases; and influencing the development of atherosclerotic complications such as plaque rupture, aneurysm formation and calcification. Expanding our understanding of the pathways involved in cell–matrix interactions will provide new therapeutic targets and strategies for the diagnosis and treatment of atherosclerosis.

Key Words: atherosclerosis • calcification • collagen • macrophage • plaque rupture • smooth muscle cell

Vascular Medicine, Vol. 14, No. 1, 73-89 (2009)
DOI: 10.1177/1358863X08094801
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