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Irbesartan attenuates Ang II-induced BMP-2 expression in human umbilical vein endothelial cells

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Sheng-hua Zhou

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Shui-Ping Zhao

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Qi-ming Liu

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Xu-ping Li

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Xiang-Qian Shen

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Abstract

Bone morphogenetic protein-2 (BMP-2), a transforming growth factor-β superfamily member cytokine, plays a key role both in vascular development and in pathophysiological processes. However, the effects and mechanisms of angiotensin II (Ang II) on BMP-2 expression remain unknown in human umbilical vein endothelial cells (HUVECs). Here we show that Ang II treatment significantly increased BMP-2 expression, associated with NF-B activation, which was suppressed by treatment with pyrrolidine dithiocarbamate (PDTC) or irbesartan. Furthermore, the increased levels of MDA (malondialdehyde) in conditioned media and the decrease in activities of total superoxide dismutases (SOD) caused by Ang II were reversed by irbesartan or PDTC treatment. Our findings indicate that Ang II-induced BMP-2 expression might contribute to NF-B activation. BMP-2 expression induced by Ang II might involve excessive oxidative stress.

Key Words: Ang II • BMP-2 • HUVECs • irbesartan

Vascular Medicine, Vol. 13, No. 3, 239-245 (2008)
DOI: 10.1177/1358863X08089282


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