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Vascular Medicine
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Acute lower limb ischemia as the initial symptom of acute myeloid leukemia

Alexandros Kafetzakis

Vascular Surgery Division, University of Crete Medical School, Heraklion, Greece

Andreas Foundoulakis

Department of HematologyOncology University of Crete Medical School, Heraklion, Greece

Christos V Ioannou

Vascular Surgery Division, University of Crete Medical School, Heraklion, Greece

Emilia Stavroulaki

Department of HematologyOncology University of Crete Medical School, Heraklion, Greece

Anastassios Koutsopoulos

Department of Pathology, University of Crete Medical School, Heraklion, Greece

Asterios N Katsamouris

Vascular Surgery Division, University of Crete Medical School, Heraklion, Greece, asterios{at}med.uoc.gr

Although coagulatory system disorders are well recognized in patients with acute leukemia, these usually present with either hemorrhagic complications or thrombosis of small vessels. Large vessel thrombosis is a very rare clinical presentation. We present a patient with previously undiagnosed acute myeloid leukemia (M5), who was referred to our hospital with symptoms of acute ischemia of his right lower limb. Occlusion of the right external iliac artery due to a combination of leucostasis and coagulation disorders was noted and successfully treated with urgent leukapheresis, immediate chemotherapy and surgical thromboembolectomy.

Key Words: arterial thromboembolic disease • leucostasis • leukapheresis

Vascular Medicine, Vol. 12, No. 3, 199-202 (2007)
DOI: 10.1177/1358863X07080630
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