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Vascular Medicine
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Purple glove syndrome following intravenous phenytoin administration

Reena Chokshi

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

John Openshaw

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Nehal N Mehta

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Emile Mohler, III

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Purple glove syndrome (PGS) is a rare complication of intravenous phenytoin use that typically presents with pain, edema, and discoloration at the injection site that spreads to the distal limb. Several risk factors have been associated with the development of PGS; however, the etiology remains unknown. We present a case of PGS and briefly review the current understanding of this syndrome.

Key Words: adverse reaction • intravenous • phenytoin • purple glove syndrome • toxicity

Vascular Medicine, Vol. 12, No. 1, 29-31 (2007)
DOI: 10.1177/1358863X07076551
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