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Vascular Medicine, Vol. 11, No. 4, 259-262 (2006)
DOI: 10.1177/1358863x06072218

Acute lower limb ischemia due to thrombo-embolic arterial occlusions in two previously healthy men with markedly elevated Lp(a)

Gabriella V Bedarida

Division of Vascular Medicine, Ludwig-Maximilians University Hospital, Munich, Germany

Ulrich Hoffmann

Ulrich Hoffmann, Division of Vascular Medicine, Medizinische Poliklinik, Ludwig-Maximilians University, Pettenkoferstrasse 8a, D-80336 Munich, Germany. Tel: +49 89 5160 3590; Fax: +49 89 5160 4494; Division of Vascular Medicine, Ludwig-Maximilians University Hospital, Munich, Germany hoffmann{at}med.uni-muenchen.de

Federico Tatò

Division of Vascular Medicine, Ludwig-Maximilians University Hospital, Munich, Germany

Lipoprotein (a) (Lp(a)) is a well-documented risk factor for atherosclerotic cardiovascular disease. Its role in acute thrombo-embolic occlusions of peripheral arteries is not known. We describe two cases of multiple, acute, peripheral arterial occlusions in two previously healthy men with markedly elevated Lp(a). Both cases had unsatisfactory results after percutaneous and surgical revascularization procedures. Experience yielded in these two cases suggests that when an unfavorable out-come occurs in a peripheral artery disease patient in the absence of the regular risk factors, Lp(a) should be determined and its role investigated.

Key Words: acute limb ischemia • arterial thrombosis • Lp(a) • myointimal hyperplasia • peripheral artery disease


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