Vascular Medicine

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brevetti, G.
Right arrow Articles by Chiariello, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brevetti, G.
Right arrow Articles by Chiariello, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Vascular Medicine, Vol. 11, No. 1, 39-47 (2006)
DOI: 10.1191/1358863x06vm645ra

Cellular adhesion molecules and peripheral arterial disease

Gregorio Brevetti

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University ‘Federico II’, Napoli, Italy, brevetti{at}unina.it

Vittorio Schiano

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University ‘Federico II’, Napoli, Italy

Massimo Chiariello

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University ‘Federico II’, Napoli, Italy

Cellular adhesion molecules (CAMs), by mediating the recruitment of circulating leukocytes to the blood vessel wall and their subsequent migration into the subendothelial spaces, play a crucial role in all stages of atherosclerosis. Soluble forms of CAMs, probably derived from proteolytic shedding, are present in the circulation and their blood levels parallel the amount expressed on the cell surface. In patients with peripheral arterial disease (PAD), increased levels of soluble CAMs have been found during exercise-induced claudication, are associated with the presence, the severity and the extent of atherosclerosis in the arteries of the lower limbs, and portend a worse outcome. These findings have provided new insights into the pathophysiology of PAD and its consequences. However, further large population studies are needed to firmly establish whether increased levels of circulating CAMs give additive information to current risk assessment approaches, and to verify whether PAD patients with elevated levels of circulating CAMs would benefit from any specific therapy.

Key Words: atherosclerosis • cellular adhesion molecules • intermittent claudication • peripheral arterial disease


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Vasc MedHome page
S. Haugen, I. P. Casserly, J. G. Regensteiner, and W. R. Hiatt
Risk assessment in the patient with established peripheral arterial disease
Vascular Medicine, November 1, 2007; 12(4): 343 - 350.
[Abstract] [PDF]