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Vascular Medicine
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What's this?

Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race?

Carlos Iribarren

Kaiser Permanente Division of Research, Oakland, CA, USA, cgi{at}dor.kaiser.org

Lisa J Herrinton

Kaiser Permanente Division of Research, Oakland, CA, USA

Jeanne A Darbinian

Kaiser Permanente Division of Research, Oakland, CA, USA

Lawrence Tamarkin

CytImmune Sciences, Inc., College Park, MD, USA

Donald Malinowski

CytImmune Sciences, Inc., College Park, MD, USA

Joseph H Vogelman

Orentreich Foundation for the Advancement of Science, Inc., Cold Spring-on-Hudson, NY, USA

Norman Orentreich

Orentreich Foundation for the Advancement of Science, Inc., Cold Spring-on-Hudson, NY, USA

David Baer

Department of Oncology, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA

Endostatin, an endogenous anti-angiogenic protein, has been linked to reduced atherosclerosis in animal models. We conducted a nested case-control study to ascertain whether decreased circulating endostatin might be associated with increased odds of acute myocardial infarction (AMI) and whether this association varied by sex or race. Cases were 211 subjects who subsequently developed AMI, and controls were 173 subjects free of cardiovascular disease matched on age, sex, race and follow-up time. In conditional logistic regression adjusting for traditional risk factors, the odds ratio of AMI per 1 SD increment in endostatin was 0.85 (95% confidence interval, 0.73-1.00). This association varied by race (but not by sex) such that a statistically significant inverse relation was found among Asians and white individuals and a significant positive relation among black individuals. Further research is needed to replicate these findings and to elucidate potential mechanisms for these race/ethnic differences.

Key Words: angiogenesis • epidemiology • myocardial infarction

Vascular Medicine, Vol. 11, No. 1, 13-20 (2006)
DOI: 10.1191/1358863x06vm654oa
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