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Vascular Medicine
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Endogenous production of nitric oxide synthase inhibitors

Shelagh Anthony

Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK

James Leiper

Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK, james.leiper{at}ucl.ac.uk

Patrick Vallance

Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK

Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis of these inhibitors.

Key Words: asymmetric methylarginine • dimethylarginine dimethylaminohydrolase • nitric oxide synthase • protein-arginine methyltransferase

Vascular Medicine, Vol. 10, No. 2 suppl, S3-S9 (2005)
DOI: 10.1191/1358863x05vm595oa


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