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Endogenous production of nitric oxide synthase inhibitors
Shelagh Anthony
Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK
James Leiper
Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK, james.leiper{at}ucl.ac.uk
Patrick Vallance
Centre for Clinical Pharmacology, The British Heart Foundation Laboratories, University College London, UK
Numerous reports have indicated that the plasma concentration of endogenously produced inhibitors of nitric oxide synthase are elevated in human disease states. In this review we discuss recent advances in our understanding of the enzymes responsible for the synthesis of these inhibitors.
Key Words: asymmetric methylarginine dimethylarginine dimethylaminohydrolase nitric oxide synthase protein-arginine methyltransferase
Vascular Medicine, Vol. 10, No. 2 suppl,
S3-S9 (2005)
DOI: 10.1191/1358863x05vm595oa

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