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Endothelial function in highly endurance-trained and sedentary, healthy young women

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Heidi Hoven

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Eva V Hetland

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Øivind Rognmo

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, Department of Cardiology, St Olavs Hospital, Trondheim University Hospital, oivind.rognmo{at}medisin.ntnu.no

Stig A Slørdahl

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, Department of Cardiology, St Olavs Hospital, Trondheim University Hospital

Endothelial function is reduced by age, chronic heart failure, coronary artery disease, hypertension or type 2 diabetes, and it is shown that aerobic exercise may reverse this trend. The effect of a high aerobic training status on endothelial function in young, healthy subjects is however less clear. The present study was designed to determine whether endothelial function is improved in highly endurance-trained young women compared to sedentary, healthy controls.

Brachial artery diameter was measured in 16 endurance-trained (age: 23.7 ± 2.5 years, maximal oxygen uptake (VO_2max): 60.6 ± 4.5 ml/kg per min) and 14 sedentary females (age: 23.7 ± 2.1 years, VO_2max: 40.5 ± 5.6 ml/kg per min) at rest, during flow-mediated dilation (FMD) and after sublingual glycerol trinitrate administration, using high-resolution ultrasound. FMD did not differ between the endurance-trained and the sedentary females (14.8% vs 16.4%, p = NS), despite a substantial difference in VO_2max of 50% (p < 0.001). The endurance-trained group possessed however, a 9% larger resting brachial artery diameter when adjusted for body surface area.

The results of the present study suggest that endothelial function is well preserved in young, healthy women, and that a high aerobic training status due to long term aerobic training does not improve the dilating capacity any further.

Key Words: aerobic exercise • flow mediated dilation • oxygen uptake

Vascular Medicine, Vol. 10, No. 2, 97-102 (2005)
DOI: 10.1191/1358863x05vm592oa


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